2
1
3
Literature & Humanities
http://ijpt.iums.ac.ir
1
admin
9
10
8
7
14
8888
13
en
jalali
1397
3
1
gregorian
2018
6
1
16
1
online
1
fulltext
en
The most valuable biomarkers of Alzheimer's disease: a review article
Cellular and Molecular
مروری
Review Article
<div style="text-align: justify;">Alzheimer’s disease (AD) is the most popular type of dementia in elderly and is described by a progressive loss of cognitive capacity and severe neurodegeneration which typically begins with memory deficits. The major biomarkers of AD include total tau, phosphorylated-tau and 42 amino acid isoform of amyloid beta that reflect neurodegeneration and indicate the pathophysiological processes in AD. Biomarkers have been analyzed in different kinds of body fluid. Cereberospinal fluid (CSF) biomarkers are particularly valuable to discriminate early AD from other diseases associated with memory impairment. However, access to CSF is invasive and researchers try to find valuable biomarkers in other body fluids. In this article, we reviewed different kinds of biomarkers and their validity to diagnose and effectiveness in AD therapy.</div>
Biomarkers, Alzheimer’s disease, Blood, Cereberospinal fluid
1
6
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-60-1&slc_lang=en&sid=1
DONYA
NAZARINIA
e_nazarinia@yahoo.com
10031947532846001568
10031947532846001568
No
Department of Physiology, Iran University of Medical Sciences, Tehran, Iran
FARIBA
KARIMZADEH
Fariba_Karimzade@yahoo.com
10031947532846001569
10031947532846001569
Yes
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran