2
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3
Literature & Humanities
http://ijpt.iums.ac.ir
1
admin
9
10
8
7
14
8888
13
en
jalali
1397
3
1
gregorian
2018
6
1
16
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online
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fulltext
en
Evaluation of Resistance to Aminoglycosides among clinical isolates of Acinetobacter baumannii: A Systematic Review and Meta-analysis
Chemotherapy, Antibiotics and Gene Therapy
پژوهشي
Research Article
<div style="text-align: justify;">In past decades, aminoglycosides have been commonly used to treat gram-negative infections as well as multi-drug resistant tuberculosis strains. However, in recent years, intrinsic, adaptive and acquired resistances have been raised against aminoglycosides which limits the uptake of these antibiotics. Acquired resistance to <em>Acinetobacter baumannii</em> responsible for nosocomial infection against aminoglycosides, has been led to a medical dilemma. In the present study, we aimed to investigate the prevalence rate of <em>A. baumannii</em> resistance to aminoglycosides using a meta-analysis and systematic review. International databases of Scopus, PubMed, Web of Science and Google Scholar, as well as national databases, include SID, Magiran, IranDoc, and IranMedex, were searched carefully and 62 articles published during years 1993 and 2016 were selected. After data extraction, random-effects model was used for analysis. Also, data heterogeneity was assessed using the I2 index and the final statistical analysis was done using STATA and R software. The total sample size of 28,055 extracted from the chosen articles and entered the meta-analysis process. The drug resistance value of <em>A. baumannii</em> isolates to various antibiotics was determined as follows: Amikacin 69% (57% to 81%), Tobramycin61% (52% to 71%), Netilmicin 35% (11% to 59%) and Gentamicin 68% (57% to 80%). The highest and lowest sensitivity of <em>A. baumannii</em> was considered against Netilmicin 57% (32% to 82%) and Gentamicin 26% (12% to 39%), respectively. According to our findings, the drug-resistance rate of <em>A. baumannii</em> clinical isolates to aminoglycosides, especially Amikacin, Tobramycin, and Gentamicin are relatively high. So, Gentamicin and Amikacin are not recommended as first-line treatment of <em>A. baumannii</em> isolates.<br>
</div>
Drug- resistance, Aminoglycosides, Acinetobacter baumannii
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11
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-94-1&slc_lang=en&sid=1
MOHAMMAD YOUSEF
ALIKHANI
alikhani@umsha.ac.ir
10031947532846001553
10031947532846001553
Yes
Department of Microbiology and Brucellosis Research Center, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran
ALI
NAZARI
nazari-a@medilam.ac.ir
10031947532846001554
10031947532846001554
No
MD, Assistant professor, Department of Infectious Disease, School of Medicine, Ilam university of medical sciences, Ilam, Iran.
KOUROSH
SAYEHMIRI
kouresh_sayehmiri@yahoo.com
10031947532846001555
10031947532846001555
No
Department of social Medicine, Ilam University of Medical Sciences, Ilam, Iran
FATEMEH
SAYEHMIRI
fsayehmiri@yahoo.com
10031947532846001556
10031947532846001556
No
student research committee, Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
MANOOCHEHR
KARAMI
ma.karami@umsha.ac.ir
10031947532846001557
10031947532846001557
No
Department of Epidemiology, Hamadan University of Medical Sciences, Hamadan, Iran
JALAL
GHADERKHANI
jalalghaderkhani@gmail.com
10031947532846001558
10031947532846001558
No
Department of Microbiology and Brucellosis Research Center, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IR Iran