2
1
3
Literature & Humanities
http://ijpt.iums.ac.ir
1
admin
9
10
8
7
14
8888
13
en
jalali
1397
3
1
gregorian
2018
6
1
16
1
online
1
fulltext
en
Effect of Melatonin Treatment on Serum Levels of Mineral Elements, Total Oxidant and Antioxidant Capacity in Mustard Exposed Patients
Toxicology
پژوهشي
Research Article
<div style="text-align: justify;">Sulfur mustard (SM) is a mutagenic compound that causes oxidative stress, antioxidant depletion even several years after exposure. Melatonin is an alternative medication that has antioxidant peroperties. The aim of this study was to investigate the effect of melatonin treatment on serum levels of several mineral elements, total antioxidant (TAC) and total oxidant status (TOS) in sulfur mustard-exposed patients. Victims with lung and sleep disorders was divided randomly to placebo and melatonin groups. They received melatonin or placebo for 56 days. Blood samples were taken before and after drug usage. The concentrations of serum trace elements (manganese, zinc, copper, and iron) and one other essential element (magnesium) were determined by graphite furnace and flame atomic absorption spectroscopy. TAC and TOS in serum were determined colorimetrically. Results showed that melatonin administration increases the magnesium and TAC concentrations. After the drug usage, placebo and melatonin groups had the highest TOS and TAC contents, respectively. Therefore, melatonin can be considered as a compound suitable for suppression of oxidative stress and helps to decrease oxidative damages induced by mustard gas.</div>
Antioxidants, Melatonin, Minerals, Mustard gas, Oxidants
1
6
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-66-1&slc_lang=en&sid=1
ALIREZA
SHAHRIARY
Shahriary961@gmail.com
10031947532846001635
10031947532846001635
Yes
System biology and poisonings institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
REZA
ASADI
reza_asadi91@yahoo.com
10031947532846001636
10031947532846001636
No
Department of Food Hygiene, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
HAMID REZA
GHEISARI
ghaisari@shirazu.ac.ir
10031947532846001637
10031947532846001637
No
Department of Food Hygiene, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
SOGHRA
MOUSAVI
seyyedeh.s.mousavi@gmail.com
10031947532846001638
10031947532846001638
No
System biology and poisonings institute, Baqiyatallah University of Medical Sciences, Tehran, Iran