2
1
3
Literature & Humanities
http://ijpt.iums.ac.ir
1
admin
9
10
8
7
14
8888
13
en
jalali
1397
3
1
gregorian
2018
6
1
16
1
online
1
fulltext
en
Production, quality control, and biodistribution studies of 141Ce-EDTMP as a potential bone pain palliation agent
Absorption, Distribution, Metabolism and Excretion
پژوهشي
Research Article
<div style="text-align: justify;">The purpose of the present work was to introduce <sup>141</sup>Ce-EDTMP as a novel potential future pain palliative agent to patients suffering from disseminated skeletal metastases and diagnostic imaging radioisotope as well<em>.</em> Cerium-141 [T<sub>1/2</sub> = 32.501 days, E<sub>β</sub> (max) = 0.580 (29.8%) and 0.435(70.2%) MeV, E<sub>γ</sub> = 145.44 (48.2%) keV] possesses radionuclidic properties suitable for use in palliative therapy of bone metastases. <sup>141</sup>Ce also has gamma energy of 145.44 keV, which resembles that of <sup>99m</sup>Tc. Therefore, the energy window is adjustable on the Tc-99m energy because of imaging studies. <sup>141</sup>Ce can be produced through a relatively easy route that involves thermal neutron bombardment on natural CeO<sub>2</sub> in medium flux research reactors (4–5×10<sup>13</sup> neutrons/cm<sup>2</sup>·s). The requirement for an enriched target does not arise. Ethylenediamine (tetramethylene phosphonic acid) (EDTMP) was synthesized and radiolabeled with <sup>141</sup>Ce. The experimental parameters were optimized to achieve maximum yields (>99%). The radiochemical purity of <sup>141</sup>Ce-EDTMP was evaluated by radio-thin layer chromatography. The stability of the prepared formulation was monitored for one week at room temperature, and results showed that the preparation was stable during this period (>99%). Biodistribution studies of the complexes carried out in wild-type rats exhibited significant bone uptake with rapid clearance from blood. The images showed high uptake of complex in bone after 72h and 2 weeks clearly. The percentage injected dose per gram of tissue (%ID/g) for each organ or tissue was calculated. The results show significant bone uptake with rapid clearance from blood. The properties of produced <sup>141</sup>Ce-EDTMP suggest applying a new efficient bone pain palliative therapeutic agent to overcome metastatic bone pains.</div>
<br>
Cerium-141, Bone pain palliative, EDTMP, Radiopharmaceutical, Biodistribution
1
7
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-38-2&slc_lang=en&sid=1
FATEMEH
SOLTANI
10031947532846001597
10031947532846001597
No
Department of Medical Radiation Engineering, Science & Research Branch, Islamic Azad University, Tehran, Iran
SIMINDOKHT
SHIRVANI ARANI
10031947532846001598
10031947532846001598
No
Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
MAHDI
SADEGHI
sadeghi.m@iums.ac.ir
10031947532846001596
10031947532846001596
Yes
Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
SAMIRA
HEIDARI
10031947532846001599
10031947532846001599
No
Medical Physics Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
ALI
BAHRAMI SAMANI
10031947532846001600
10031947532846001600
No
Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
KAMAL
YAVARI
10031947532846001601
10031947532846001601
No
Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran