2
1
3
Literature & Humanities
http://ijpt.iums.ac.ir
1
admin
9
10
8
7
14
8888
13
en
jalali
1391
9
1
gregorian
2012
12
1
11
2
online
1
fulltext
en
Synthesis Of 2-[4-(Substituted Benzylidene)-5-Oxo-4,5-Dihydro-Oxazol-2-Ylmethyl]-Isoindole-1,3-Dione Derivatives as Novel Potential Antimicrobial Agents
پژوهشي
Research Article
In the present study, a series of new substituted oxazolone derivatives (4a-4h) were synthesized by the Erlenmeyer condensation of phthaloylglycylglycine with different aldehydes in the presence of anhydrous sodium acetate and acetic anhydride. The structure of newly-synthesized compounds were evaluated by elemental analyses and spectral ( UV-Visible, IR, NMR, Mass) studies. All the synthesized derivatives were evaluated for their antimicrobial activity. Preliminary pharmacological evaluation revealed that the compound 4b, 4c, 4d, 4g and 4h showed better performance against Staphylococcus aureus , Staphylococcus epidermidis, Proteus mirabilis , Pseudomonas aeruginosa , Candida albicans and Aspergillus niger . The minimum inhibitory concentration (MIC) was determined for the target compounds as well as for standard drugs. Physicochemical similarity of the new derivatives with standard drugs was assessed by calculating from a set of 10 physicochemical parameters using software programs. The result demonstrated the potential and usefulness of developing novel oxazolone derivatives which would be effective against resistant and pathogenic bacterial and fungal strain.
45
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-257&slc_lang=en&sid=1
Suman
Bala
1003194753284600868
1003194753284600868
No
Minaxi
Saini
1003194753284600869
1003194753284600869
No
Sunil
Kamboj
1003194753284600870
1003194753284600870
No
Vipin
Saini
1003194753284600871
1003194753284600871
No