2
1
3
Literature & Humanities
http://ijpt.iums.ac.ir
1
admin
9
10
8
7
14
8888
13
en
jalali
1388
7
1
gregorian
2009
10
1
8
2
online
1
fulltext
en
Anticonvulsive Effect of Seed Extract of Caesalpinia bonducella (Roxb.)
پژوهشي
Research Article
In traditional system of Indian medicine, C.bonducella is widely used for its antipyretic, antiperiodic, anticonvulsive, and antiparalytic activities. For assessing anticonvulsant activity, pentylenetetrazole, maximal electro shock, strychnine- and picrotoxin-induced convulsions models were used. Diazepam was used as a standard reference for all models except maximal electro shock model, wherein phenytoin was used as standard reference. Seed kernels of C. bonducella were powdered and subjected to successive extraction with solvents like petroleum ether (PE), ethanol, methanol and water using soxhlet apparatus. All the extracts were administered as suspension in 2% gum acacia in all the experiments. Preliminary phytochemical investigation of petroleum ether extract of caesalpinia bonducella revealed the presence of saponins, glycoside, starch, sucrose, proteins, sterols and reported constituents like homoisoflavone (bonducillin) and a non alkaloid bitter principle (natin ). It was found to be non-toxic even up to the dose level of 3000mg/kg (LD 50 ). In pentylenetetrazole, maximal electro shock, strychnine- and picrotoxin-induced convulsion models medium and high doses (600 and 800mg/kg) of the extract showed significant anti-convulsant activity. The present investigation revealed that the PECB possessed anticonvulsant activity which may be contributed to the presence of phytoconstituents such as saponins, proteins, homoisoflavone (bonducillin), carbohydrates and sterols present in the drug, as these are already reported for their anxiolytic and anti-convulsant activities.
51
0
http://ijpt.iums.ac.ir/browse.php?a_code=A-10-100-204&slc_lang=en&sid=1
A.
Ali
1003194753284600693
1003194753284600693
No
N. Venkat
Rao
1003194753284600694
1003194753284600694
No
Md.
Shalam
1003194753284600695
1003194753284600695
No
T. Shivaraj
Gouda
1003194753284600696
1003194753284600696
No
S. M.
Shantakumar
1003194753284600697
1003194753284600697
No