TY - JOUR JF - iums-ijpt JO - 3 VL - 1 IS - 1 PY - 2002 Y1 - 2002/4/01 TI - Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats TT - N2 - Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP dependent potassium channel (KATP) modulators are thought to interfere with some physiologic functions of the stomach. We have studied the effects of different doses of KATP modulators (diazoxide as agonist and glibenclamide as antagonist) on EIGU in rats. Gastric lesions were quantified. Fasting blood glucose (FBS) levels were measured enzymatically. EIGU was prevented by diazoxide and aggravated by glibenclamide. Diazoxide increased and glibenclamide decreased FBS respectively. The present study shows that KATP modulators are involved in the production of EIGU with a mechanism which remains to be elucidated. SP - 5 EP - 0 AU - Rahgozar, Majid AU - Pazoki Toroudi, Hamid Reza AU - Bakhtiarian, Azam AU - Djahanguiri, Bijan AD - UR - http://ijpt.iums.ac.ir/article-1-4-en.html ER -