@ARTICLE{, author = {Durairaj, Ashokkumar and Mazumder, Upal Kanti and Gupta, Malaya and ray, Subrata Kumar and }, title = {Effects of Methanolic Extract of Oxystelma esculentum on Diuresis and Urinary Electrolytes Excretion in Rats}, volume = {6}, number = {2}, abstract ={The diuretic activity of methanol extract of Oxystelma esculentum aerial parts (MEOE) was studied in male Wister albino rats at 5h and 24h interval. The animals were divided into 5 groups: control, urea, furosemide and 200mg/kg and 400mg/kg MEOE. The extract was administered intraperitoneally (i.p) pretreated and all animals were saline MEOE. The urine volume (in mL) and electrolytes excretion (Na + , K + , Ca 2+ and Cl - ) at 5h and 24h duration were measured. The urine output increased significantly in urea, furosemide and both MEOE groups ( p <0.001). MEOE increased the urine volume and electrolytes balance in a dose dependent manner. The results indicate that MEOE is an effective hypernatramic, hyperkalaemic, hypercalcemic and hyperchloremic diuretic, which supports the traditional claim about the Oxystelma esculentum being used as a diuretic. }, URL = {http://ijpt.iums.ac.ir/article-1-129-en.html}, eprint = {http://ijpt.iums.ac.ir/article-1-129-en.pdf}, journal = {2}, doi = {}, year = {2007} }