[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 5, Issue 2 (12-2006) ::
3 2006, 5(2): 113-0 Back to browse issues page
Modulatory Effect of Vitamin C on Genotoxic Effect of Endosulfan in Developing Albino Rats
S.D. Manjula , S. Benjamin , K. L. Bairy
Abstract:   (115 Views)
The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12mg/kg Endosulfan orally (10 pups/group),for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9mg/kg and 12mg/kg was administered along with vitamin C (20mg/kg). One more group of rats were treated with cyclophosphamide as positive control. The genotoxic effect was studied by bone marrow micronuclei assay.There was an increase in micronuclei in polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) and a decrease in PCE and P/N ratio in endosulfan treated rats. The effect was similar to the standard mutagen cyclophosphamide. In rats treated with vitamin C and endosulfan, there was an increase in PCE and P/N ratio and decrease in micronuclei in PCE and NCE. This could be due to the antimutagenic effect of vitamin C. Increase in micronuclei in endosulfan treated rats showed genotoxic effect of endosulfan. Decrease in micronuclei in animals treated with both endosulfan and vitamin C, showed antimutagenic effect of vitamin C.
Full-Text [PDF 0 kb]   (19 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

Write the security code in the box >


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Manjula S, Benjamin S, Bairy K L. Modulatory Effect of Vitamin C on Genotoxic Effect of Endosulfan in Developing Albino Rats. 3. 2006; 5 (2) :113-0
URL: http://ijpt.iums.ac.ir/article-1-98-en.html
Volume 5, Issue 2 (12-2006) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.15 seconds with 33 queries by YEKTAWEB 3647