[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 5, Issue 1 (9-2006) ::
3 2006, 5(1): 15-0 Back to browse issues page
Nootropic Activity of Calyces of Hibiscus Sabdariffa Linn
Hanumanthachar Joshi , Milind Parle
Abstract:   (168 Views)
Nootropic acitivity of calyces of Hibiscus sabdariffa Linn. was studied in mice. Elevated plus maze and passive avoidance paradigm were employed to evaluate learning and memory parameters. Scopolamine (0.4 mg/kg, i.p.) was used to induce amnesia in mice. The aqueous extracts of calyces of Hibiscus sabdariffa (HS-100 and 200 mg/kg, p.o.) significantly attenuated amnestic deficits induced by scopolamine (0.4 mg/kg, i.p.) and natural aging. HS (100 and 200 mg/kg) decreased the transfer latencies and increased step down latencies significantly in the aged mice and scopolamine induced amnesic mice as compared with Piracetam (200 mg/kg, i.p.). To delineate the possible mechanism through which H. sabdariffa elicits the anti-amnesic effects, we studied its influence on central cholinergic activity by estimating the whole brain acetylcholinesterase activity. H. sabdariffa significantly decreased acetyl cholinesterase activity in mice. The results indicate that, the aqueous extract of calyces of H. sabdariffa might prove to be a useful memory restorative agent in the treatment of dementia seen in elderly. The underlying mechanism of action can be attributed to its anti acetylcholinesterase property.
Full-Text [PDF 387 kb]   (115 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA code


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Joshi H, Parle M. Nootropic Activity of Calyces of Hibiscus Sabdariffa Linn. 3. 2006; 5 (1) :15-0
URL: http://ijpt.iums.ac.ir/article-1-83-en.html


Volume 5, Issue 1 (9-2006) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.26 seconds with 33 queries by YEKTAWEB 3749