[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 4, Issue 2 (11-2005) ::
3 2005, 4(2): 118-0 Back to browse issues page
Protective Effect of N-Acetyl Cysteine in Carbon Tetrachloride-Induced Hepatotoxicity in Rats
Narasimhanaidu Kamalakkannan , Rajagopalan Rukkumani , Kode Aruna , Penumathsa Suresh Varma , Periyasamy Viswanathan , Venugopal Padmanabhan Menon
Abstract:   (158 Views)
The present study determines the efficacy of N-acetyl cysteine (NAC) on marker enzymes, lipid peroxidation and antioxidants in carbon tetrachloride induced hepatotoxicity in rats. Carbon tetrachloride (CCl4) (3 mL/kg/week) administered subcutaneously to albino Wistar rats for a period of three months significantly increased the activities of marker enzymes in plasma such as aspartate transaminase, Gama-glutamyl transferase and alkaline phosphatase and increased the levels of thiobarbituric acid reactive substances and hydroperoxides in plasma and tissues (liver and kidney). A significant decrease in the levels of plasma antioxidants (glutathione, vitamin C and vitamin E) was also noted. Further, a decrease in the concentration of glutathione and the activities of superoxide dismutase, catalase and glutathione peroxidase in the tissues were observed. N-acetyl cysteine (150 mg/kg) was orally administered to normal and carbon tetrachloride-treated rats for a period of three months. N-acetyl cysteine decreased the activities of marker enzymes, lipid peroxidation and improved the antioxidant status in carbon tetrachloride-treated rats. But there were no significant alterations in these parameters in normal rats treated with N-acetyl cysteine. Histopathological observations of the liver also showed the protective effect of N-acetyl cysteine in carbon tetrachloride-induced hepatotoxicity in rats. The results of this study show the protective action of N-acetyl cysteine in carbon tetrachloride-induced hepatotoxicity in rats. This is mainly due to the effective antioxidant potential of N-acetyl cysteine.
Full-Text [PDF 2753 kb]   (75 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA code


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kamalakkannan N, Rukkumani R, Aruna K, Varma P S, Viswanathan P, Padmanabhan Menon V. Protective Effect of N-Acetyl Cysteine in Carbon Tetrachloride-Induced Hepatotoxicity in Rats. 3. 2005; 4 (2) :118-0
URL: http://ijpt.iums.ac.ir/article-1-60-en.html


Volume 4, Issue 2 (11-2005) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.2 seconds with 33 queries by YEKTAWEB 3749