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:: Volume 1, Issue 1 (4-2002) ::
3 2002, 1(1): 5-0 Back to browse issues page
Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats
Majid Rahgozar , Hamid Reza Pazoki Toroudi , Azam Bakhtiarian , Bijan Djahanguiri
Abstract:   (165 Views)
Ethanol-induced acute gastric ulceration (EIGU) is widely studied. ATP dependent potassium channel (KATP) modulators are thought to interfere with some physiologic functions of the stomach. We have studied the effects of different doses of KATP modulators (diazoxide as agonist and glibenclamide as antagonist) on EIGU in rats. Gastric lesions were quantified. Fasting blood glucose (FBS) levels were measured enzymatically. EIGU was prevented by diazoxide and aggravated by glibenclamide. Diazoxide increased and glibenclamide decreased FBS respectively. The present study shows that KATP modulators are involved in the production of EIGU with a mechanism which remains to be elucidated.
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Rahgozar M, Pazoki Toroudi H R, Bakhtiarian A, Djahanguiri B. Diazoxide, a KATP Channel Opener, Prevented Ethanol-Induced Gastric Ulceration in Rats. 3. 2002; 1 (1) :5-0
URL: http://ijpt.iums.ac.ir/article-1-4-en.html


Volume 1, Issue 1 (4-2002) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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