:: Volume 17, Issue 1 (6-2019) ::
3 2019, 17(1): 1-10 Back to browse issues page
The multifaceted therapeutic potential of valproic acid beyond CNS axis
SAMIR O. RABADIYA *, ASHVIN DUDHREJIYA
Saurashtra university, Rajkot, Gujarat, India
Abstract:   (259 Views)
Valproic acid is widely used as an anti-epileptic globally. Anti-epileptic action is mediated by Gamma Amino Butyric Acid (GABA) receptors. In past and recently, several other clinical outcomes have been proposed by various studies. These under-reported clinical actions apart from anti-epileptic activity are mediated by various intracellular and extracellular pathways. Several mechanisms like Histone deacetylase (HDAC) inhibition, inhibition of inflammatory cytokines, angiogenesis inhibition and many more justifies its possible use in variety of disorders like diabetes mellitus, asthma, cancer, shock, hyperlipidemia, fibrosis etc. Present review throws some light on such under-reported, clinically beneficial effects of Valproic acid in various diseases and disorders.
Keywords: Cytokines, Diabetes, Fibrosis, Histone deacetylase inhibitor, Valproic acid
Full-Text [PDF 398 kb]   (116 Downloads)    
Article Type: Review Article | Subject: Neuropharmacology


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Volume 17, Issue 1 (6-2019) Back to browse issues page