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:: Volume 16, Issue 1 (6-2018) ::
3 2018, 16(1): 1-6 Back to browse issues page
The most valuable biomarkers of Alzheimer's disease: a review article
DONYA NAZARINIA , FARIBA KARIMZADEH
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (236 Views)
Alzheimer’s disease (AD) is the most popular type of dementia in elderly and is described by a progressive loss of cognitive capacity and severe neurodegeneration which typically begins with memory deficits. The major biomarkers of AD include total tau, phosphorylated-tau and 42 amino acid isoform of amyloid beta that reflect neurodegeneration and indicate the pathophysiological processes in AD. Biomarkers have been analyzed in different kinds of body fluid. Cereberospinal fluid (CSF) biomarkers are particularly valuable to discriminate early AD from other diseases associated with memory impairment. However, access to CSF is invasive and researchers try to find valuable biomarkers in other body fluids.  In this article, we reviewed different kinds of biomarkers and their validity to diagnose and effectiveness in AD therapy.
Keywords: Biomarkers, Alzheimer’s disease, Blood, Cereberospinal fluid
Full-Text [PDF 474 kb]   (134 Downloads)    
Article Type: Review Article | Subject: Cellular and Molecular
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NAZARINIA D, KARIMZADEH F. The most valuable biomarkers of Alzheimer's disease: a review article. 3. 2018; 16 (1) :1-6
URL: http://ijpt.iums.ac.ir/article-1-326-en.html


Volume 16, Issue 1 (6-2018) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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