:: Volume 14, Issue 1 (11-2015) ::
3 2015, 14(1): 1-6 Back to browse issues page
The effects of magnesium supplements on adi-ponectin level and insulin sensitivity in first-degree relatives of subjects with type 2 diabetes
Arezoo Afkhami-Ardekani AA, Babak Majidi BM, Saeedeh Jam Ashkezari SJ, Mohammad Hosain Afrand MA, Mohammad Mohammadi MM, Mohammad Afkhami-Ardekani MA
PhD Department of Internal Medicine, Endocrinology, Shahid Sadoughi University of medical sciences, Yazd, Iran
Abstract:   (457 Views)
The interaction between intracellular magnesium level, adiponectin production and insulin sensitivity has been recently suggested in both diabetic patients and their first-degree relatives. The present study aimed to investigate whether magnesium supplements are able to increase plasma adiponectin and affect insulin sensitivity in first-degree relatives of subjects with type 2 diabetes. Seventy subjects who were first-degree relatives of diabetic patients were randomly allocated to either Mg hydroxide supplementation plus lifestyle (case group, n = 35) or mere lifestyle change and placebo (control group, n=35). The subjects were seen at 16-weeks intervals for at least 24 months. There was no difference in baseline level of adiponectin between intervention and control group (p = 0.612), but significantly increased in intervention group (mean change of 6.51 ± 4.33 mg/dl, p ≤ 0.001) and significantly reduced in control group (0.70 ± 0.52 mg/dl, p ≤0.001) after 16-week intervention protocol. No difference was revealed in initial insulin resistance between the two study groups (p = 0.527), but it was revealed lower in intervention group after completing treatment (p ≤ 0.001). On the other hand, after 16 week of initial interventions, insulin resistance index reduced as 0.56 ± 0.85 units (p ≤ 0.001), while increased in control group as 0.68 ± 0.78 units (p ≤0.001). The increase in adiponectin production as well as decrease in insulin resistance is expected by administrating magnesium supplements in first-degree relatives of the patients with diabetes mellitus.
Keywords: Magnesium, Adiponectin, First-degree Relatives, Type 2 diabetic patients
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Article Type: Research Article | Subject: Absorption, Distribution, Metabolism and Excretion


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Volume 14, Issue 1 (11-2015) Back to browse issues page