[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 12, Issue 1 (3-2013) ::
3 2013, 12(1): 19-0 Back to browse issues page
Effects of Pluchea lanceolata Root Extract on Cisplatin induced Nausea and Vomiting in Rat Pica Model
Naveen Goyal , Surendra Kr Sharma
Abstract:   (162 Views)
Cisplatin is an effective chemotherapeutics against a wide range of cancers. However, it causes significant nausea and vomiting which limit its usefulness. In the present study, the effects of methanolic root extract of Pluchea lanceolata (DC.) C. B. Clarke , asteraceae ( MPL ) was investigated against cisplatin-induced nausea using a rat pica model. In rat pica model, rats react to cisplatin (emetic/nausea stimuli), with altered feeding habits, manifested by increased consumption of kaolin. The pica in rats was measured to quantify cisplatin-induced nausea, and to evaluate the protective effect of pretreatment with MPL given orally. Cisplatin at 3 mg/kg (i.p.) induced significant pica indicated by reduced food intake and increased kaolin consumption, suggesting the presence of nausea/emesis. Cisplatin-induced pica decreased significantly when animals were pretreated with MPL at doses of 400 mg/kg p.o. ( p < 0.05). MPL pretreatment decreased cisplatin-induced kaolin intake in the rat model of simulated nausea, suggesting that MPL and/or its active constituent(s) may play a therapeutic role as protective against chemotherapy-induced emesis.
Full-Text [PDF 409 kb]   (28 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA code


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Goyal N, Sharma S K. Effects of Pluchea lanceolata Root Extract on Cisplatin induced Nausea and Vomiting in Rat Pica Model. 3. 2013; 12 (1) :19-0
URL: http://ijpt.iums.ac.ir/article-1-252-en.html


Volume 12, Issue 1 (3-2013) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.3 seconds with 33 queries by YEKTAWEB 3749