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:: Volume 11, Issue 1 (10-2012) ::
3 2012, 11(1): 15-0 Back to browse issues page
The Involvement of Non Opioidergic Mechanism in the Antinociceptive and Antilocomotive Activity of Bacopa monnieri
Muzaffar Abbas , Fazal Subhan , Khalid Rauf , Ikram Ul-Haq , Syed Nadeem-ul-Hassan Mohani
Abstract:   (128 Views)
A hydroethanolic extract (HE-ext) of Bacopa monnieri (BM) was studied for antinociceptive effect in the animal models of acetic-acid-induced writhing test and antilocomotive effect in mice. Standard centrally-acting analgesic, morphine (MP), and peripherally-acting one, diclofenac (Diclo), were also tested along with the extract for comparison. The extract exhibited significant antinociceptive effect ( p < 0.001) in this test, not antagonized by the opioid receptor antagonist, naloxone (NLX) in a fashion similar to diclofenac. This excluded the involvement of opioids in the mediation of antinociceptive response of Bacopa monnieri . Moreover, the BM HE-ext exhibited highly significant antilocomotive ( p < 0.0001) that was also unaffected by naloxone. These results indicate that Bacopa monnieri possesses antinociceptive and antilocomotive effect that may be mediated through non-opioidergic mechanism.
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Abbas M, Subhan F, Rauf K, ul-Haq I, Mohani S N. The Involvement of Non Opioidergic Mechanism in the Antinociceptive and Antilocomotive Activity of Bacopa monnieri. 3. 2012; 11 (1) :15-0
URL: http://ijpt.iums.ac.ir/article-1-237-en.html
Volume 11, Issue 1 (10-2012) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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