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:: Volume 10, Issue 1 (1-2011) ::
3 2011, 10(1): 1-0 Back to browse issues page
Antibacterial activity and cytotoxicity screening of Sumatran Kaduk (Piper sarmentosum Roxb)
E. Atiax, F. Ahmad, H. M. Sirat, D. Arbain, V. Bhagwan Badgujar
Abstract:   (410 Views)
Phytochemical investigations of Piper sarmentosum Roxb., yielded four compounds; three amides, identified as 3-(3’,4’,5’-trimethoxyphenylpropanoyl) pyrrolidine, 3-(4’-methoxyphenylpropanoyl) pyrrole, N -(3-phenylpropanoyl) pyrrole and a sterol namely β -sitosterol . 3-(4’-Methoxyphenylpropanoyl) pyrrole was found for the first time in this Piper species. All chemical constituents were tested for their antibacterial activity using disk diffusion method and cytotoxicity screening using sul-forhodamine B (SRB) assay. All of the compounds were found only active towards gram-positive bacteria except 3-(4’-methoxyphenylpropanoyl) pyrrole with no activity against both gram-positive and gram-negative bacteria. Meanwhile, the cytotoxicity screening using SRB assay indicated that none of these compounds was active as an anticancer agent.
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Atiax E, Ahmad F, Sirat H M, Arbain D, Badgujar V B. Antibacterial activity and cytotoxicity screening of Sumatran Kaduk (Piper sarmentosum Roxb). 3. 2011; 10 (1) :1-0
URL: http://ijpt.iums.ac.ir/article-1-223-en.html

Volume 10, Issue 1 (1-2011) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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