[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 2, Issue 1 (5-2003) ::
3 2003, 2(1): 1-0 Back to browse issues page
G-protein Coupled Receptor Dimerization
Nikzad Nikbin , Christine Edwards , Christopher A Reynolds
Abstract:   (141 Views)
A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular loops, transmembrane helices and intracellular loops. The nature of bonds between two receptors can vary from covalent (e.g. disulphide bonds) to non-covalent (for instance hydrophobic interactions between trans-membrane helices or coiled coil structures) or a combination of both. Dimerization can occur in and affect different stages of a receptors life, namely trafficking, signaling and internalization, and can be seen as the natural way to regulate receptor activity or increase the functional repertoire of proteins. Different structures for GPCR dimers have been proposed, for example a simple contact dimer or an interlocking domain-swapped structure. Here we introduce some of the information available on GPCR dimerization, which includes early studies that had been dismissed until the relatively recent past and some of the more recent data which has vindicated these early studies.
Full-Text [PDF 529 kb]   (102 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA code


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nikbin N, Edwards C, Reynolds C A. G-protein Coupled Receptor Dimerization. 3. 2003; 2 (1) :1-0
URL: http://ijpt.iums.ac.ir/article-1-22-en.html


Volume 2, Issue 1 (5-2003) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.28 seconds with 33 queries by YEKTAWEB 3749