[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 9, Issue 1 (1-2010) ::
3 2010, 9(1): 15-0 Back to browse issues page
Effect of Hydroalcoholic Extracts of Tylophora indica Leaves in Isoprenaline-Induced Myocardial Damage in Rat Heart
S. Basheeruddin Asdaq , S. K. Sowmya
Abstract:   (146 Views)
Normal 0 false false false MicrosoftInternetExplorer4 The present study was carried out to determine the effect of hydroalcoholic extract of Tylophora indica (HETI) on experimentally-induced myocardial infarction (MI) in rats. Albino rats were treated with HETI at doses of 100 mg/kg, (HETI-100) or 200 mg/kg (HETI-200) and propranolol 10 mg/kg (PRO-10) for 30 days orally. MI was induced by subcutaneous administration of isoprenaline (IPL) 150 mg/kg for two consecutive days. Pretreatment of animals with PRO-10 and HETI-200 provided significant myocardium protection from IPL damage as indicated by significant decrease in lactate dehydrogenase (LDH) and creatine phosphokinase-MB (CK-MB) activities in serum and an increase in activities of these enzymes in heart tissue homogenate (HTH). Moreover, HETI-200 significantly increased endogenous antioxidants (SOD and catalase) activities when compared to IPL control as well as normal. The protection offered by HETI could be attributed to the presence of flavanoids which shows antioxidant effect by either inhibiting the release of oxygen free radicals (OFR) or enhancing the synthesis of endogenous antioxidants such as SOD and catalase in IPL-induced cardiotoxicity. These biochemical findings were further confirmed by histological investigations.
Full-Text [PDF 280 kb]   (47 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

Write the security code in the box >


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Asdaq S B, Sowmya S K. Effect of Hydroalcoholic Extracts of Tylophora indica Leaves in Isoprenaline-Induced Myocardial Damage in Rat Heart. 3. 2010; 9 (1) :15-0
URL: http://ijpt.iums.ac.ir/article-1-200-en.html
Volume 9, Issue 1 (1-2010) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.15 seconds with 33 queries by YEKTAWEB 3647