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:: Volume 8, Issue 1 (5-2009) ::
3 2009, 8(1): 23-0 Back to browse issues page
Neuropharmacological Effect of the Rhizome of Drynaria quercifolia in Mice
Alam Khan , Ekramul Haque , BYTUL M RAHMAN , MATIUR RAHMAN
Abstract:   (140 Views)
The neuropharmacological effect of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the rhizome of Drynaria quercifolia J. Smith were studied in mice by intraperitoneal administration. The tests used were determination of effect on duration of diazepam-induced sleep, determination of effect on nikethamide-induced toxicity, light-dark test and force swimming test. The duration of diazepam-induced sleep was extended by administration of these fractions. Nikethamide at high dose cause death of mice and time to cause death of mice was delayed by administration of these fractions. In light-dark test and force swimming test these fractions were given diazepam type effect. The changes in doses (50-200 mg/kg) showed changes in efficiency of these effects. These results suggest that both these fractions of D. quercifolia rhizome have dose dependent depressant effect.
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Khan A, Haque E, RAHMAN B M, RAHMAN M. Neuropharmacological Effect of the Rhizome of Drynaria quercifolia in Mice. 3. 2009; 8 (1) :23-0
URL: http://ijpt.iums.ac.ir/article-1-182-en.html


Volume 8, Issue 1 (5-2009) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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