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:: Volume 7, Issue 2 (12-2008) ::
3 2008, 7(2): 137-0 Back to browse issues page
Effect of aqueous extract of Syzygium cumini Pulp on antioxidant defense system in streptozotocin induced diabetic rats
Namasivayam Rekha , Ramachandran Balaji , Munuswamy Deecaraman
Abstract:   (117 Views)
The aqueous extract of Syzygium cumini (Pulp) was investigated for its possible hypoglycemic and antioxidant potentials in streptozotocin (STZ) induced diabetic wistar female rats. A single intraperitoneal injection of STZ at a dose of 55 mg/kg body weight elevated the glucose levels more than 230 mg/dl after 3 days. Treatment with the aqueous extract of Syzygium cumini (Pulp) at 100 mg/kg and 200 mg/kg body weight resulted in significant reduction ( p <0.001) in blood glucose levels. Body weights were significantly reduced ( p <0.001) in STZ Induced diabetic rats when compared to normal rats, while in diabetic rats S.cumini extract ( p <0.001) prevented significantly the decrease in body weight in a dose dependant manner. Total cholesterol, phospholipids, triglycerides, LDL-c, HDL-c levels were altered in &nbsp; STZ induced diabetic rats, which were considerably restored to near normal in animals treated with S.cumini extract .The administration of aqueous extract of Syzygium cumini &nbsp; resulted in significant ( p <0.001) increase in the levels of superoxide dismutase, catalase, glutahione peroxidase, glutathione-S-transferase and reduced glutathione (GSH), thus resulting in reduced free radical formation in liver tissues of the diabetic rats . The increased levels of lipid peroxidation and hydroperoxides in diabetic rats were reverted back to near normal levels after the treatment with aqueous extract of Syzygium cumini . These observations demonstrated that aqueous extract of Syzygium cumini (Pulp) have strong hypoglycemic effect and in vivo antioxidant activity in STZ-Induced diabetic rats and was dose dependent.
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Rekha N, Balaji R, Deecaraman M. Effect of aqueous extract of Syzygium cumini Pulp on antioxidant defense system in streptozotocin induced diabetic rats. 3. 2008; 7 (2) :137-0
URL: http://ijpt.iums.ac.ir/article-1-178-en.html
Volume 7, Issue 2 (12-2008) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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