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:: Volume 1, Issue 2 (11-2002) ::
3 2002, 1(2): 20-0 Back to browse issues page
The Comparative Effects of Four Antihistamines on Isolated Rat Atria
Abbas Pousti , Golrokh Malihi , Azam Bakhtiarian , Zahra Abdollahi
Abstract:   (151 Views)
It has been reported that some of H1 receptor antagonists have important effects on cardiovascular system. Terfenadine as a non-sedative H1 receptor antagonist has an arrhythmogenic activity. In this study we have shown the effects of four antihistamine drugs: terfenadine, loratadine, clemastine and diphenhydramine, on the rate and contractions of isolated rat atria. Terfenadine (1-10 µM) caused a negative chronotropic effect (19.5-80%) and arrhythmia after 10 min. followed by a decrease in the contractile force by (7.5%), and finally after 45 min. asystolia occurred. Loratadine (30-150 µM) decreased the rate of contractions (10-82%) after 10 min. the contractile force of atria was decreased (10-19%) after 20 min. Loratadine did not produce any arrhythmia. Diphenhydramine (5-20 µM) produced bradycardia (14.5-43%) after 20 min and decreased the contractile force (2.5-40%) after 40 min. Clemastine (3-10 µM) produced negative chronotropic and inotropic effect by (11.5-42%) and (10-58%) respectively. These findings indicate that all four drugs caused bradycardia and reduced contractile force, but in the case of terfenadine, it also had arrhythmogenic activity. Loratadine had the least cardiotoxic effect.
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Pousti A, Malihi G, Bakhtiarian A, Abdollahi Z. The Comparative Effects of Four Antihistamines on Isolated Rat Atria. 3. 2002; 1 (2) :20-0
URL: http://ijpt.iums.ac.ir/article-1-17-en.html


Volume 1, Issue 2 (11-2002) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
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