[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 1, Issue 2 (11-2002) ::
3 2002, 1(2): 20-0 Back to browse issues page
The Comparative Effects of Four Antihistamines on Isolated Rat Atria
Abbas Pousti , Golrokh Malihi , Azam Bakhtiarian , Zahra Abdollahi
Abstract:   (1222 Views)
It has been reported that some of H1 receptor antagonists have important effects on cardiovascular system. Terfenadine as a non-sedative H1 receptor antagonist has an arrhythmogenic activity. In this study we have shown the effects of four antihistamine drugs: terfenadine, loratadine, clemastine and diphenhydramine, on the rate and contractions of isolated rat atria. Terfenadine (1-10 µM) caused a negative chronotropic effect (19.5-80%) and arrhythmia after 10 min. followed by a decrease in the contractile force by (7.5%), and finally after 45 min. asystolia occurred. Loratadine (30-150 µM) decreased the rate of contractions (10-82%) after 10 min. the contractile force of atria was decreased (10-19%) after 20 min. Loratadine did not produce any arrhythmia. Diphenhydramine (5-20 µM) produced bradycardia (14.5-43%) after 20 min and decreased the contractile force (2.5-40%) after 40 min. Clemastine (3-10 µM) produced negative chronotropic and inotropic effect by (11.5-42%) and (10-58%) respectively. These findings indicate that all four drugs caused bradycardia and reduced contractile force, but in the case of terfenadine, it also had arrhythmogenic activity. Loratadine had the least cardiotoxic effect.
Full-Text [PDF 329 kb]   (906 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Pousti A, Malihi G, Bakhtiarian A, Abdollahi Z. The Comparative Effects of Four Antihistamines on Isolated Rat Atria. 3 2002; 1 (2) :20-0
URL: http://ijpt.iums.ac.ir/article-1-17-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 1, Issue 2 (11-2002) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4642