[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 1, Issue 2 (11-2002) ::
3 2002, 1(2): 31-0 Back to browse issues page
Structural Overview Of Mammalian Zinc Metalloproteinases
Edgar Meyer , Shahram Khademi , I. Botos , E.F. Meyer
Abstract:   (150 Views)
Matrix metalloproteinases (MMP) are crucial for homeostasis (tissue remodelling and repair, bone growth, wound healing, etc.) and pathology (metastasis, angiogenesis, aneurysm rupture, etc.). Upregulated MMPs from macrophages are thus a two-edged sword, playing both defensive and aggressive roles. The related family of ADAMs (a disintegrin and a metalloproteinase) is sometimes overlooked because of classification peculiarities. The best-studied ADAM-17, tumor necrosis factor a convertase (TNF-a), is a membrane-bound “shedase” that releases a membrane-bound cytokine, tumor necrosis factor a (TACE). Many of the ADAMs have remarkable structural and mechanistic and inhibitor proclivities similar to the MMPs; the potential for inhibitor side reactions and drug toxicities abounds. Over the past 10 years the crystallographic study of proMMPs, MMPs, and ADAMs in free and complexed forms has revealed the mechanistic and structural nature of these macromolecules to atomic resolution. These results will be reviewed and indications for future work will be presented. Special attention will be given to visualization tools to assist with the conceptualization of complex molecular interactions. (Support provided by the Robert A. Welch Foundation, the US National Science Foundation, and the R.W. Johnson Pharmaceutical Research Institute).
Full-Text [PDF 14 kb]   (100 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

CAPTCHA code


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Meyer E, Khademi S, Botos I, Meyer E. Structural Overview Of Mammalian Zinc Metalloproteinases. 3. 2002; 1 (2) :31-0
URL: http://ijpt.iums.ac.ir/article-1-14-en.html


Volume 1, Issue 2 (11-2002) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.18 seconds with 33 queries by YEKTAWEB 3749