[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 17, Issue 1 (6-2019) ::
3 2019, 17(1): 1-9 Back to browse issues page
Stereological and biochemical studies of kidney in diabetic mice treated with ethanolic extract of Urtica dioica L.: Introducing an anti-diabetic and nephroprotective agent
SAMANEH GOORANI, NABI SHARIATFAR, MOHAMMAD MAHDI ZANGENEH *, AKRAM ZANGENEH, FARIBA HOSSEINI
Department of Clinical Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
Abstract:   (328 Views)
Urtica dioica L. is widely used as an anti‑inflammatory, antioxidant, antimicrobial, hypocholesterolemic, antiulcer, anti‑colitis, anticancer, hypotensive, immunomodulatory, and hepatoprotective agent. In the present study, the antidiabetic and nephroprotective potentials of U. dioica ethanolic extract was investigated against streptozotocin (STZ) induced diabetic mice. Male mice were divided into six groups: normal control, untreated diabetic, diabetic mice receiving 30, 90 and 270 mg/kg of plant extract (groups UD30, UD90 and UD270, respectively) or 30 mg/kg glibenclamide. At 20th day, the mice killed, dissected, then blood and kidney samples were collected for histological and biochemical parameters analysis. The data was analyzed by one way variance analysis and Duncan’s test using SPSS 21. Different doses of U. dioica (especially UD270) could significantly (p≤0.05) reduce the raised levels of blood glucose, urea, creatinine and volumes and lengths of the proximal and distal convoluted tubules, collecting ducts, vessels and loop of Henle and increase the weight of body and levels of superoxide dismutase (SOD) and catalase (CAT) when compared to the untreated group. The results of the present study showed that under the present experimental conditions, ethanolic extract of U. dioica indicated antidiabetic and nephroprotective abilities against STZ induced kidney damage in mice.
 
Keywords: Antidiabetic potential, Nephroprotective potential, Ethanolic extract, Urtica dioica L., Streptozotocin
Full-Text [PDF 583 kb]   (100 Downloads)    
Article Type: Research Article | Subject: Endocrine and Reproductive
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

GOORANI S, SHARIATFAR N, ZANGENEH M M, ZANGENEH A, HOSSEINI F. Stereological and biochemical studies of kidney in diabetic mice treated with ethanolic extract of Urtica dioica L.: Introducing an anti-diabetic and nephroprotective agent. 3. 2019; 17 (1) :1-9
URL: http://ijpt.iums.ac.ir/article-1-336-en.html


Volume 17, Issue 1 (6-2019) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.16 seconds with 31 queries by YEKTAWEB 4237