[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 11, Issue 2 (12-2012) ::
3 2012, 11(2): 40-0 Back to browse issues page
Cystone, a well-known herbal formulation improves renal function in rats with acute renal failure (ARF) induced by Glycerol intoxication
M. Rafiq , G. L. Viswanatha , M. Mohammed Azeemuddin , D. A. Suryakanth , V. K. Uday Kumar , P. S. Patki
Abstract:   (31 Views)
The present study was aimed to evaluate the beneficial effect of Cystone syrup in an experimental model of glycerol-induced acute renal failure (ARF) in rats. Biochemical parameters, kidney weight and histopathological evaluation were performed to conclude the beneficial effect of Cystone syrup. Administration of single dose of 50% v/v glycerol (8ml/kg.i.m) caused severe renal dysfunction associated with significant increase in markers of renal function such as serum urea ( p <0.01), creatinine ( p <0.01), blood urea nitrogen (BUN) ( p <0.01), decrease in the Creatinine clearance (Ccr) ( p <0.01) and increase in kidney weight to body weight ratio ( p <0.01) compared to control group. These changes were in accordance with the histopathological findings showing severe tubular necrosis, degeneration and moderate luminal cast formation. In contrast, pre-treatment with Cystone (5 ml/kg, p .o) for seven days, alleviated the glycerol induced renal dysfunction significantly by maintaining serum urea ( p <0.01), creatinine ( p <0.05), BUN ( p <0.01) and kidney weight to body weight ratio ( p <0.05) near to normal range, also improved the creatinine clearance ( p <0.05) compared to untreated positive control. In addition, histopathology of Cystone (5 ml/kg, p.o) treated group showed mild to moderate tubular necrosis and degeneration. Thus, the findings of the present study demonstrates the usefulness of Cystone syrup in reversing the biochemical/ structural markers of renal dysfunction observed in experimental model of renal failure in rats.
Full-Text [PDF 1405 kb]   (8 Downloads)    
Article Type: Research Article |
Add your comments about this article
Your username or Email:

Write the security code in the box >



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rafiq M, Viswanatha G L, Mohammed Azeemuddin M, Suryakanth D A, Uday Kumar V K, Patki P S. Cystone, a well-known herbal formulation improves renal function in rats with acute renal failure (ARF) induced by Glycerol intoxication. 3. 2012; 11 (2) :40-0
URL: http://ijpt.iums.ac.ir/article-1-248-en.html
Volume 11, Issue 2 (12-2012) Back to browse issues page
مجله داروشناسی و درمان شناسی ایران Iranian Journal of Pharmacology and Therapeutics
Persian site map - English site map - Created in 0.253 seconds with 807 queries by yektaweb 3525